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KMID : 1145120200180020235
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Asian Journal of Beauty and Cosmetology
2020 Volume.18 No. 2 p.235 ~ p.247
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Development of Oral Disintegration Film Containing Naturally Derived Compounds Using Peptide Collagen and a Study of its Functions
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Kim Dong-Sub
Han In-Jun
Lee Byung-Soo
Park Sang-Yun
Nho Eun-Yeong
Eom Ji
Suh Ji-Young
Kim Geon
Park Ji-Hyun
Sung Nak-Yun
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Abstract
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Purpose: In this study, we aim to study the functionality of multiple effects of peptide collagen and naturally derived compounds through in vitro experiments and human application tests.
Method: Cytotoxicity of inner beauty film (IBF), pro-collagen generation ability, elastase and collagenase inhibition, DPPH radical scavenging and tyrosinase inhibition ability were measured, and skin improvement, through in vitro and human application test.
Results: Cytotoxicity was not confirmed up to 1000 μg/mL. Elastase inhibition was 7.2% at a concentration of 125 μg/mL, and collagenase showed an inhibition rate of 16.3% at 31.3 μg/mL. The pro-collagen synthesis showed expression of 34%, compared with the negative control when the concentration was 62.5 μg/mL. The antioxidant activity of 250 μg/mL and whitening effect of 62.5 μg/mL are showed in the Results section, and there was no observed deformation or color change even after confirming the stability for 6 months. Even in the human clinical study, the wrinkle improvement before and after using the IBF was 32.2% at maximum, skin melanin and brown spot improvement was 32.5%, pore improvement was 31.5%, and skin density improvement was 12.8%, as shown in the Results section.
Conclusion: Therefore, the IBF containing the complex of peptide collagen and naturally derived compounds has a positive effect on wrinkle improvement, skin melanin and brown spot improvement, skin pore improvement, and skin density improvement, as well as exhibiting antioxidant and whitening effects. As a result, IBF can be developed as a key material for cosmetics and foods.
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KEYWORD
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Inner beauty film, Wrinkle improvement, Whitening, Functional cosmetics, Peptide collagen
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